2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glyoxalase (GLO)

Glyoxalase (GLO)

The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging.

The glyoxalase system consists of two cooperating enzymes named Glyoxalase 1 (Glo1) and Glyoxalase 2 (Glo2). Glo1 converts a non-enzymatically formed hemithioacetal, the adduct between an intracellular thiol such as glutathione (GSH) and a metabolically produced α-ketoaldehyde such as MG, into a thioester product . In the case of MG and GSH, S-D-lactoylglutathione is the product. Glo2 hydrolyzes this thioester into D-lactate and regenerates the intracellular thiol GSH. Glo1 and Glo2 work in tandem to convert cytoxic MG into D-lactate.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136684
    BrBzGCp2
    		Inhibitor 99.00%
    BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.
    BrBzGCp2
  • HY-15167A
    Glyoxalase I inhibitor free base
    		Inhibitor 98.52%
    Glyoxalase I inhibitor free base (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research.
    Glyoxalase I inhibitor free base
  • HY-W009177
    S-Methylglutathione
    		Inhibitor 99.40%
    S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH. S-Methylglutathione has inhibitory effect on glyoxalase 1.
    S-Methylglutathione
  • HY-P4277
    N,S-Bis-Fmoc-Glutathione
    		Inhibitor 99.45%
    N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a Ki value of 0.75 μM and an IC50 of 2.5 μM.
    N,S-Bis-Fmoc-Glutathione
  • HY-185057
    S-D-Lactoylglutathione
    		Substrate 98.66%
    S-D-Lactoylglutathione is a crucial intermediate metabolite of the glyoxalase (Glo) system. S-D-Lactoylglutathione acts as a "bridge molecule" for the conversion of methylglyoxal (MGO) into non-toxic D-lactic acid by continuous catalysis from Glo1 to Glo2, preventing cell damage caused by the accumulation of MGO.
    S-D-Lactoylglutathione
  • HY-117208
    TLSC702
    		Inhibitor
    TLSC702 is a human glyoxalase I (hGLO I) inhibitor with an IC50 of 2.0 μM. TLSC702 inhibits the activity of human glyoxalase I, thereby leading to the accumulation of methylglyoxal and its derived advanced glycation end products. TLSC702 inhibits tumor cell proliferation, induces apoptotic morphological changes, internucleosomal DNA fragmentation and PARP cleavage in tumor cells. TLSC702 can be used in research related to leukemia and lung cancer.
    TLSC702
  • HY-W842446
    Enzyme-IN-4
    		Inhibitor
    Enzyme-IN-4 is a competitive inhibitor of glyoxalase I that can be found in Stereum hirsutum. Enzyme-IN-4 has a Ki value of 4.6 μM against rat liver glyoxalase I.
    Enzyme-IN-4
  • HY-P4277A
    N,S-Bis-Fmoc-Glutathione TFA
    		Inhibitor
    N,S-Bis-Fmoc-Glutathione TFA is a potent glyoxalase II inhibitor with a Ki value of 0.75 μM and an IC50 of 2.5 μM.
    N,S-Bis-Fmoc-Glutathione TFA
  • HY-147647
    Glyoxalase I inhibitor 5
    		98.38%
    Glyoxalase I inhibitor 5 (Compound 9h) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.28 μM. Glyoxalase I inhibitor 5 can be used as anticancer agent.
    Glyoxalase I inhibitor 5
  • HY-34005
    2-Dimethylaminophenol
    		Inhibitor
    2-Dimethylaminophenol is an inhibitor of human glyoxalase 1 (GLO1). 2-Dimethylaminophenol disrupts metal binding by substituting the pyridine nitrogen donor with a dimethylamino group.
    2-Dimethylaminophenol
  • HY-146656S
    S-Sulfo-DL-cysteine-d3
    		98.10%
    S-Sulfo-DL-cysteine-2,3,3-d3 is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.
    S-Sulfo-DL-cysteine-d<sub>3</sub>
  • HY-146655
    Glyoxalase I inhibitor 3
    		Inhibitor 98.06%
    Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety.
    Glyoxalase I inhibitor 3
  • HY-15167
    Glyoxalase I inhibitor
    		Inhibitor ≥98.0%
    Glyoxalase I inhibitor (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research.
    Glyoxalase I inhibitor
  • HY-147648
    Glyoxalase I inhibitor 6
    		Inhibitor 99.26%
    Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity.
    Glyoxalase I inhibitor 6
  • HY-115915
    TS010
    		Inhibitor
    TS010 is a potent inhibitor of GLO-I with IC50 of 0.57 μM. TS010 has the potential for the research of cancer disease.
    TS010
  • HY-147649
    Glyoxalase I inhibitor 7
    		Inhibitor
    Glyoxalase I inhibitor 7 (Compound 6) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 3.65 μM. Glyoxalase I inhibitor 7 can be used as anticancer agent.
    Glyoxalase I inhibitor 7
  • HY-153154
    COMC-6
    		Inhibitor
    COMC-6 is an anticancer agent and can be used for study of cancer.
    COMC-6
  • HY-146656
    Glyoxalase I inhibitor 4
    		Inhibitor
    Glyoxalase I inhibitor 4 (compound 14) is a potent glyoxalase I inhibitor with an Ki of 10 nM.
    Glyoxalase I inhibitor 4
  • HY-146653
    Glyoxalase I inhibitor 1
    		Inhibitor
    Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 26 nM. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Glyoxalase I inhibitor 1
  • HY-146654
    Glyoxalase I inhibitor 2
    		Inhibitor
    Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety.
    Glyoxalase I inhibitor 2
Cat. No. Product Name / Synonyms Application Reactivity